Professor Li Hongliang from our hospital made a breakthrough in liver metabolism research

February 21, the international top magazine Nature Medicine (IF = 30.357) published online the latest research results of Li Hongliang, professor of cardiovascular medicine from our hospital. This study revealed for the first time a key negative control effect of a natural immune important molecule CFLAR in the course of non-alcoholic steatohepatitis (NASH), elaborated its molecular mechanism, and demonstrated important clinical significance in prevention and treatment of NASH.

The paper titled Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates. The doctoral student Wang Pixiao, postdoctoral scholars Zhang Xiaojing and Ji Yanxiao are the co-first authors of this paper. Professor Li Hongliang is the corresponding author. Renmin Hospital of Wuhan University is the unit of first and corresponding author. This is the second time that professor Li Hongliang published his research results in the Journal of Nature Medicine. (Interpreted by Dr. ZHANG Zheng)


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